An important protective barrier which also needs to be kept clean is the prosthetic sock. This garment serves as a cushion between the skin and the device wall and contributes greatly to a comfortable, functional prosthesis. However, since the sock or socks worn absorb perspiration, a daily change is vital to skin care, health, and hygiene.

Whether washed by machine or by hand, socks need a thorough cleansing in warm water, preferably using a sanitizing lotion soap or mild detergent. They should be well rinsed in warm, clear water to remove any trace of soap residue which can irritate skin tissue. This is best done in the evening so the socks fully dry overnight or, if necessary, over a period of several days.

When rinsing, excess water should be squeezed (not wrung) from the socks. If a prosthetic sock should dry in a distorted manner, insert a tennis ball to reshape it. Sock drying forms are also available.